- Uphando lwase-Edinburgh lufumanisa i-beta-amyloid kwi-synapses yeekati ezine-dementia, uphawu oluphambili lwe-Alzheimer's.
- Iikati zibonelela ngemodeli ethembekileyo yendalo kuneempuku zokufunda esi sifo.
- I-Microglia kunye ne-astrocyte zabonwa "ziqwenga" ii-synapses, ezidibanisa neuroinflammation kunye nokulahlekelwa kwengqondo.
- Ukuqaphela iimpawu ekhaya kunye nokulungelelanisa indawo engqongileyo kuphucula umgangatho wobomi kwiikati ezindala.
Ubungqina obukhulayo bubonisa ukuba iikati zinokuba ne-dementia. ebudaleni, kunye nokubonakaliswa okufana kakhulu nezo ze-Alzheimer yabantu. Kude nokuba yinto enqabileyo, le pateni ekwabelwana ngayo ibhala kwakhona indlela esikuqonda ngayo ukuguga kwengqondo kunye nendlela ukuphazamiseka kwengqondo kulungiswa ngayo kunyango lwezilwanyana kunye namayeza.
Ikhonsortium yeengcali ezivela kwi KwiYunivesithi yase-Edinburgh, kunye nabasebenzisana nabo eCalifornia kunye namaziko e-United Kingdom, bahlalutye ubuchopho be Iikati ezingama-25 zafa zineempawu zokuphazamiseka kwengqondo (ukudideka, utshintsho ubuthongo, meowing ngakumbi). Bachonga ukuqokelelwa kwe-beta-amyloid kwii-synapses, uphawu oluqhelekileyo lwe-Alzheimer's, kwaye lufumene imikhondo kwiindlela ezinokukhokela unyango lwexesha elizayo.
Oko kutyhilwa luphononongo olutsha
Iisampulu ze-Postmortem zibonise ukuba kwiinkabi ezinokukhubazeka kwengqondo zikhona i-beta-amyloid ibeka kanye kwindawo ye-neuronal junctionsNgokuthintela olu nxibelelwano, ukutshintshiselana kolwazi phakathi kwe-neurons kuyathintelwa, nto leyo enxulunyaniswa nokusilela kwenkumbulo nokucinga, kanye njengokuba kwenzeka kubantu abane-Alzheimer's.
Iqela likwayibonile loo nto i-astrocytes kunye ne-microglia -iiseli zenkxaso-zazisebenza, "gobbling up" i-synapses eyonakeleyo, into ebizwa ngokuba yi-phenomenon ukuthenwa kwe-synapticLe nkqubo iqhelekile ngexesha lophuhliso, kodwa ebudaleni inokuba negalelo kunxibelelwano olulahlekileyo kunye nokuncipha kwengqondo, ukwenza isipili oko kuchazwe kwizigulane zabantu.
Ababhali bayayigxininisa loo nto Iikati ziyimodeli ethembekileyo yendalo kuneempuku eziguqulwe ngokwemfuza, ngokwesiko elisetyenziselwa ukufunda i-Alzheimer's, nangona ingaphuhli ngokuzenzekelayo isifo sengqondo esiyingozi. Umsebenzi, ipapashwe kwi-European Journal of Neuroscience kwaye ixhaswa ngemali yi-Wellcome kunye ne-UK Dementia Research Institute, yomeleza le ndlela yokuthelekisa.
Umntu ojongene nophononongo, uRobert McGeachan, ugxininisa ukuba oku kungqamana vula umnyango wokuvavanya unyango unyango oluthembisayo ebantwini lukwaquka neekati ezindala; kunye nengcali uDanielle Gunn-Moore ubonisa ukuba ukuqonda ngcono isifo sengqondo esiyingozi ziya kuba yingenelo kwizilwanyana zasekhaya kunye nabo bazinyamekelayo.
Kutheni iikati zibalulekile kuphando lwe-Alzheimer
La ukulahleka kwe-synapses iqikelela kakhulu ukwehla kwenkumbulo kwi-Alzheimer's. Ukubona ipateni efanayo kwiifelines kuqinisa izicwangciso ezijoliswe kuzo khusela imidibaniso okanye uhlengahlengise i-glial neuroinflammation. Ekubeni le yimeko eyenzeka ngokwemvelo kwiikati, uphando lunokuthi sondeza iziphumo kwisigulane esingumntu kuneemodeli zaselebhu zesintu.
Le nkqubela ifuna ukuqwalaselwa kwemiba yokuziphatha. Eminye imibutho yamalungelo ezilwanyana ixhasa uphando olusekelwe kwidatha ekhoyo kunye nobuchule obungabonakaliyo, kodwa ukwala uvavanyo olutsha lwezilwanyana oluyingoziUluntu lwenzululwazi, ngokwenxalenye yalo, lubonisa ukuba izifundo zokujonga kunye nokuthelekisa kwi imifuziselo yendalo inokukhawulezisa izisombululo kuzo zombini iintlobo ngokunciphisa ukubandezeleka.
Kukho imida kule nkqubela phambili: inani leengqondo ezihlalutywayo incinci ngokwentelekiso (25), olu luhlalutyo lwe-post mortem kunye nezifundo ze-longitudinal ezidibanisayo zisanqongophala biomarkers, umfanekiso kunye nokulandelelwa kweklinikhiNangona kunjalo, ukufana kwi-synapses, i-amyloid, kunye nempendulo ye-glial ibonisa inyathelo eliqinileyo eliya phambili.
Ukuba ezi ziphumo ziqinisekisiwe kwizifundo ezinamaqela amakhulu kunye nezinto eziguquguqukayo ezininzi - kubandakanywa ukubonakaliswa kwezinye iiprotheni ezibandakanyekayo - Iikati zingasetyenziselwa ukuvavanya amachiza anciphisa i-amyloid okanye imodareyitha i-microglia kunye ne-astrocytes, iphucula iindlela zonyango phambi kwezigaba zeklinikhi ebantwini.
Iimpawu ekhaya kunye nokhathalelo olucetyiswayo
Ekhaya, kuyacetyiswa ukuba ubeke ingqalelo kwiinguqu ezifihlakeleyo: ukuphazamiseka kwengqondo, ukulala ebusuku, ukuphazamiseka kokulala, ukuzilibala izinto zemihla ngemihla, umdla onganeno wokudlala, okanye ukutyeshela ukuzilungisa. Ezi mpawu zibonisa I-feline cognitive dysfunction syndrome, nangona bengabodwa kule meko.
Phambi kokuba ubhale phantsi isifo sengqondo esixhalabisayo, kubalulekile ukusilawula i-hyperthyroidism, uxinzelelo lwegazi, ukusilela kwezintso, i-osteoarthritis okanye iingxaki zeemvakalelo, ezinokuvelisa iimpawu ezifanayo. Ugqirha wezilwanyana uya kwenza uvavanyo lwegazi, uxinzelelo lwegazi kunye nokuhlolwa kwemithambo-luvo ukufika kuxilongo oluchanekileyo.
Ulawulo lujolise ekuphuculeni umgangatho wobomi: ukugcina iindlela eziqikelelwayo, ukunciphisa utshintsho kwimo engqongileyo, lula ukufikelela kwizibonelelo (ibhedi, ibhokisi yenkunkuma, ukutya kunye namanzi) kunye nokusetyenziswa izibane zasebusuku ukunciphisa ukudideka. Ukuvuselela ingqondo ngokudlala ngokuzolileyo kunye nezitya zokutyisa ezisebenzisanayo zinokuba luncedo.
Ukutya kunye i-antioxidants kunye ne-fatty acids, ukulawulwa kweentlungu, kwaye, ukuba kufanelekile, amayeza okuxhalabisa, anokucetyiswa ngugqirha wakho wezilwanyana. Ngokuxilongwa kwangaphambili kunye nenkxaso yokusingqongileyo, iikati ezininzi ezindala gcina impilo entle iminyaka, besomeleza ulwalamano lwabo nabakhapheli babo.
Ukuqonda que los Iikati zinokuba ne-dementia Ayikhuthazi kuphela unyango olutsha lwe-Alzheimer's, kodwa ikwanceda ekuboneni iimpawu kwangethuba kunye nokhathalelo olungcono lwezilwanyana eziphezulu ezihlala nathi.
